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Grape Seed Extract
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Grape Seed Extract Oral grape seed extract is typically used as capsules or tablets usually containing 50 mg or 100 mg, or as a liquid to add drops to water and/or other drinks. Insufficient scientific information is known, however, about how long-term use of grape seed extract might affect health or any disease. |
Grape seed extract is used for conditions related to the heart and blood vessels, such as atherosclerosis (hardening of the arteries), high blood pressure, high cholesterol, and poor circulation. Search for Grape Seed Extract
Other reasons for the use of grape seed extract include complications related to diabetes, such as nerve and eye damage; vision problems, such as macular degeneration (which can cause blindness); and swelling after an injury or surgery.
Side Effects and Cautions
- Grape seed extract is generally well tolerated when taken by mouth. It has been used safely for up to 8 weeks in clinical trials.
- Side effects that have been reported most often include headache; a dry, itchy scalp; dizziness; and nausea.
- The interactions between grape seed extract and medicines or other supplements have not been carefully studied.
- Tell your health care providers about any complementary and alternative practices you use. Give them a full picture of what you do to manage your health. This will help ensure coordinated and safe care.
What the Science Says
- Laboratory studies have shown that grape seed contains antioxidants-substances that prevent cell damage caused by free radicals, which are highly reactive molecules that can damage cell function. However, it is still unclear how grape seed might affect human health.
- Grape seed extract has shown some beneficial antioxidant effects in preliminary clinical trials. However, few trials have looked at specific diseases or conditions, and little scientific evidence is available.
- A study funded by the National Cancer Institute (NCI) found that grape seed extract did not reduce the hardening of breast tissue that can occur after radiation therapy for breast cancer.
- NCI is also funding studies evaluating whether grape seed extract is effective in preventing breast and prostate cancers.
- NCCAM is studying whether the action of grape seed extract and its components may benefit the heart or have protective effects in the brain.
The medicinal and nutritional value of grapes (Vitis vinifera) has been heralded for thousands of years. Egyptians consumed this fruit at least 6,000 years ago, and several ancient Greek philosophers praised the healing power of grapes -- usually in the form of wine.
Among other beneficial effects, the active compounds in grape seed are believed to have antioxidant properties. In fact, a recent study of healthy volunteers found that supplementation with grape seed extract substantially increased levels of antioxidants in the blood.
Sources: Public information from government websites and other text in the public domain.
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